A SMALL-MOLECULE APPROACH TO RESTORE FEMALE STERILITY PHENOTYPE TARGETED BY A HOMING SUPPRESSION GENE DRIVE IN THE FRUIT PEST DROSOPHILA SUZUKII.

A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii.

Cakes CRISPR-based gene drives offer promising prospects for controlling disease-transmitting vectors and agricultural pests.A significant challenge for successful suppression-type drive is the rapid evolution of resistance alleles.One approach to mitigate the development of resistance involves targeting functionally constrained regions using multi

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Metastatic choroidal pulmonary biphasic blastoma as a unique single initial metastasis to the eye: a case report

Abstract Background Choroidal metastasis is the Jackets/Outerwear most common intraocular malignancy in adults, commonly presenting in later stages of the disease and associated with poor prognosis.This is the first case to describe choroidal involvement as the sole initial metastasis of the rare biphasic pulmonary tumor.Case presentation A 42-year

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Alterations of peripheral nerve excitability in an experimental autoimmune encephalomyelitis mouse model for multiple sclerosis

Abstract Background Experimental autoimmune encephalomyelitis (EAE) is the most commonly used and clinically relevant Cybertron murine model for human multiple sclerosis (MS), a demyelinating autoimmune disease characterized by mononuclear cell infiltration into the central nervous system (CNS).The aim of the present study was to appraise the alter

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